Jimmy Palmiotti and Amanda Connor are just about as big as you get in the comic book industry. They've got their own label and have been putting out their own creator owned work for quite a while.
The Paperfilms Box 'O' Comics includes: Killing Time In America HC - SIGNED by JIMMY PALMIOTTI, CRAIG WEEDEN, and cover artist DAVE JOHNSON (you can only find this randomly on Ebay or through the Paperfilms site)
Weapon of God TPB SIGNED by PALMIOTTI Retrovirus HC
PAINKILLER JANE (all signed by PALMIOTTI and AMANDA CONNOR): The Price of Freedom TPB 22 Brides TPB Trust the Universe HC